QTc prolongation: check drug interactions and caution with longer duration of use
LFTs: with long term use
Terbinafine HCl 250 mg tab
Indications: Onychomycosis, Tinea, Sporotrichosis
Monitoring:
Hepatotoxicity: Baseline LFTs, monitoring Q6W with any baseline liver disease, if healthy no liver disease, baseline is sufficient if not contiuned beyond 12W
Taste and Smell Disturbances: stop if experience
Thrombotic Microangiopathy: rare
Clotrimazole 1% Cream
Indications: Candidiasis, Tinea, +
Valacyclovir HCl 500 mg tab
Indications: Herpes Simplex (treat and suppress), Herpes Zoster, +
Monitoring:
AKI: Ensure good hydration, monitor GFR in longer-term use
Dose adjust for baseline kidney disease
Neurotoxicity including neuropsychiatric: stop if experience